HLCL-61 hydrochloride ( HLCL61 hydrochloride;HLCL 61 hydrochloride )

Catalog No. M10548 CAS No. 1158279-20-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

HLCL-61 hydrochloride
Note

Research use only, not for human use.
Brief Description

A novel potent and selective protein arginine methyltransferase PRMT5 inhibitor.
Description

A novel potent and selective protein arginine methyltransferase PRMT5 inhibitor; shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members; exhibits effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, significantly increases expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML cells; inhibits the proliferation of AML cell lines and primary blasts with IC50 of 7.21-21.46 uM.
Synonyms

HLCL61 hydrochloride;HLCL 61 hydrochloride
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

PRMT5
Research Area

Cancer
Indication

——

CAS Number

1158279-20-9
Formula Weight

380.91
Molecular Formula

C23H25ClN2O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
Chemical Name

9H-Carbazole-3-methanamine, 9-ethyl-N-[(2-methoxyphenyl)methyl]-, hydrochloride (1:1)

1. Tarighat SS, et al. Leukemia. 2016 Apr;30(4):789-99.

Calculator

molnova catalog